2019-7月“生物信息学数据分析（基因组与转录组）”实训---合肥
<p style="line-height: 150%; text-indent: 32px; text-align: center;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">关于举办“高通量测序技术与数据分析”高级培训班通知</span></p><p style="line-height: 150%; text-indent: 0em;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">各有关单位:</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">随着新一代高通量测序技术的快速发展，在准确度大大提高的前提下， 进一步降低测序成本。由此不断产生出巨量的分子生物学数据，这些数据有着数量巨大、关系复杂的特点，以至于不利用计算机根本无法实现数据的存储和分析。随着生物信息学作为新兴学科迅速蓬勃发展，正在改变人们研究生物医学的传统方式，高通量测序技术以及数据分析技术已成为探索生物学底层机制和研究人类复杂疾病诊断、治疗及预后的重要工具，广泛应用于生命科学各个领域，是21世纪生命科学与生物技术的重要战略前沿和主要突破口。为进一步推动我国生物信息学特别是基因组学的发展，提高从业人员的技术水平。由中科成创（北京）生物技术有限公司具体承办，具体事宜通知如下：</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">一、授课专家及培训目标：</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">主讲专家来自中科院基因组所专家，拥有丰富的科研及工程技术经验，长期从事生物信息领域项目研究，具有资深的技术底蕴和专业背景。</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">本培训以第三代测序、第四代测序技术的应用与数据分析、基因组、转录组为主题，精心设计了具有前沿性、实用性和针对性强的理论课程和上机课程。</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">二、授课模式： 1. 上机操作为主，理论为辅；</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">2. 学员与授课老师互动性授课；</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">3. 解决学员在授课当中的疑难问题；</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">4. 帮助学员开拓在课题工作中实验设计思路及解决相关问题；</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">5. 配合研究中所需的要点，围绕实际研究中常用的软件展开；</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">三、时间地点： 2019年7月10日—7月14日 安徽合肥</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">（时间安排：第1天报到，授课4天）</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">四 培训内容</span></p><table cellspacing="0" width="636"><tbody style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; word-wrap: break-word !important;"><tr class="firstRow" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 22px; break-inside: avoid; word-wrap: break-word !important;"><td width="146" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> 章节</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top-color: windowtext; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> 内 容</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 66px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-weight: bold; font-size: 11px; word-wrap: break-word !important;"><a href="http://www.miningene.com/data/Train/Sequence_Alignment.pdf" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; background: 0px 0px transparent; text-decoration-line: none; cursor: pointer; outline: none; max-width: 100%; word-wrap: break-word !important;">序列的比对</a></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">1、全局比对 Clustalw,Muscle,Hmmer</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">2、局部比对 Blast, Sim4,Genewise</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">3、序列比对算法分析</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 218px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-weight: bold; font-size: 11px; word-wrap: break-word !important;"><a href="http://www.miningene.com/data/Train/Genome_Gene_Annotation.pdf" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; background: 0px 0px transparent; text-decoration-line: none; cursor: pointer; outline: none; max-width: 100%; word-wrap: break-word !important;">基因组/基因注释分析</a></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">1、新一代测序技术原理和数据处理介绍</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">2、基因组拼接与组装</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">基因组de novo组装方法</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">重复序列分析技术</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">3、 RNA分析</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; word-wrap: break-word !important;"/></span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">tRNA,rRNA,microRNA,snoRNA</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">RNA干扰，SiRNA预测技术</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; word-wrap: break-word !important;"/></span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">4、基因预测</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; word-wrap: break-word !important;"/></span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">原核：Glimmer，真核：Genescan, Augustus</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; word-wrap: break-word !important;"/></span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">5、 基因功能注释及常用的数据库介绍</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 261px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">全基因组重测序分析介绍</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">及上机实战</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">1</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、Linux操作系统简介</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">2</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、常用Linux命令的介绍和实战</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">3</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、全基因组测序分析流程简介</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">4</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、高通量测序数据的常见格式（fasta、fastq、sam、bam、vcf、bed）</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">5</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、全基因组测序数据常用分析软件速览（bwa、samtools、GATK、bcftools、circos）</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">6</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、dbSNP数据库简介</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">7</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、数据质量评估、质量控制</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">8</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、mapping到参考基因组</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">9</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、sam文件的操作（convert to bam、sort、rmdup、index）</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">10</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、定位indel</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">11</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">、Variant Calling</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 109px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">DNA测序技术-转录组分析的进化</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">1、第一代测序技术：Sanger测序原理</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">2、第二代测序技术：Illumina，454, Ion Torrent原理</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">3、第三代测序技术：PacBio, Hellicos原理</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">4、第四代测序技术:</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"> </span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Oxford NanoPore原理</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">5、其他技术Hybridization based methods (NabSys)</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 131px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Experimental</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">procedure for transcriptomic analysis</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Introduction</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Number of duplications</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Sequencing coverage</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Transcriptomic analysis using NGS (RNA-Seq)</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Transcriptomic analysis using PacBio (Iso-Seq)</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">IsoSeq Experimental design</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 88px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Data analysis </span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">（part 1）：data pre-processing</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">evaluation of data quality 数据分析</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Data format，fasta，fastq，quality value，gff3</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Data cleanup</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Quality filter, trimmer, clipper</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 6px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Data analysis （part 2）：reference free analyses（无参转录组分析）</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Gene discovery</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Trinity de novo transcriptome assembly</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Analysis of Differential Expressed Gene （DEGs）</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Abundance estimation using RSEM</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Differential expression analysis using EdgeR</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">Explore the results (cummerbund)</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">MA plot, Volcano plot, False Discovery Rate (FDR)</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">hierarchical two-way clustering, pairwise sample-distance,</span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">gene expression profiles.</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 56px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">使用R语言进行生物信息学相关的分析</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">使用R语言相关的包对转录组等组学的高通量测序数据进行差异表达、富集分析等。</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">生物信息学专业图KEGG、GO等的绘制方法与运用R语言进行实现</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 47px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">基因组可视化软件circos的使用</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;"> </span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">使用circos绘制基因组圈图</span></span></p></td></tr><tr style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; height: 48px; word-wrap: break-word !important;"><td width="146" valign="center" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left-color: windowtext; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">生物信息学专业常用工具及绘图方法</span></span></p></td><td width="490" valign="top" style="margin: 0px; padding: 0px 7px; -webkit-font-smoothing: antialiased; border-top: none; border-right-color: windowtext; border-bottom-color: windowtext; border-left: none; max-width: 100%; word-wrap: break-word !important;"><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">应用生物信息常用的工具进行专业绘图及格式转换；</span></span></p><p style="margin-top: 5px; margin-bottom: 5px; -webkit-font-smoothing: antialiased; max-width: 100%; line-height: 24px; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; font-weight: bolder; max-width: 100%; word-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; max-width: 100%; font-family: 宋体; color: rgb(75, 172, 198); font-size: 11px; word-wrap: break-word !important;">学BioEdit、WeGO等常用生物学专业软件的图表及格式转换</span></span></p></td></tr></tbody></table><p style="padding: 0px; -webkit-font-smoothing: antialiased; font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; max-width: 100%; color: rgb(51, 51, 51); font-size: 14px; white-space: normal; background-color: rgb(255, 255, 255); line-height: 29px; word-wrap: break-word !important;"><br/></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">五、报名办法及费用：</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">每人￥4380元（含报名费、培训费、资料费、证书费）</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">团队报名：4+1优惠。（5位其中1位免除费用）</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">所报名参加学员赠送一个8G U盘（内含上课所有使用软件与课件资料）</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">食宿可统一安排，费用自理。各单位人员报名参加，报名回执表请回传至会务处即可。</span></p><p style="line-height: 150%; text-indent: 32px;"><span style="line-height: 150%; font-family: 宋体; font-size: 16px;">如单位有内训需求，请将内训方案传至会务组，根据单位需求安排相应专家进行授课</span></p>
宏观经济分析与企业发展战略培训会
<p style="padding: 0px; -webkit-font-smoothing: antialiased; font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; max-width: 100%; color: rgb(51, 51, 51); font-size: 14px; white-space: normal; background-color: rgb(255, 255, 255); word-wrap: break-word !important; text-align: center;"><img src="http://cdn.huodongxing.com//file/20181031/11F75B500DEA491900447F9A12D9AACA53/30793443667814969.jpeg" title="00合肥.png" alt="00合肥.png" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; border: 0px none; vertical-align: middle; max-width: 100%; height: auto; word-wrap: break-word !important;"/></p><p style="text-align:center"><img src="http://cdn.huodongxing.com//file/20181031/11F75B500DEA491900447F9A12D9AACA53/30103443665754766.jpeg" title="21.png" alt="21.png" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; border: 0px none; vertical-align: middle; max-width: 100%; width: 600px; height: 536px; word-wrap: break-word !important;" width="600" height="536" border="0" vspace="0"/></p><p style="text-align:center"><img src="http://cdn.huodongxing.com//file/20181031/11F75B500DEA491900447F9A12D9AACA53/30353443665824775.jpeg" title="22.png" alt="22.png" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; border: 0px none; vertical-align: middle; max-width: 100%; width: 600px; height: 640px; word-wrap: break-word !important;" width="600" height="640" border="0" vspace="0"/></p><p style="text-align:center"><img src="http://cdn.huodongxing.com//file/20181031/11F75B500DEA491900447F9A12D9AACA53/30633443665884776.jpeg" title="23.png" alt="23.png" style="margin: 0px; padding: 0px; -webkit-font-smoothing: antialiased; border: 0px none; vertical-align: middle; max-width: 100%; width: 600px; height: 645px; word-wrap: break-word !important;" width="600" height="645" border="0" vspace="0"/></p>
